Le fermenteur à bioréaction

Protéus is happy to announce the publication of a paper in the current issue of Protein Engineering Design and Selection (PEDS) for a work done in collaboration with Medimmune UK (formerly Cambridge Antibody Technology Ltd).

The paper is the first published application of L-Shufflingâ„¢ for affinity maturation of a recombinant antibody. The study demonstrates the ability of in vitro recombination techniques such as L-Shufflingâ„¢ to explore a very large sequence space and to find optimal solutions in antibody optimisation.

Ref: Chodorge, M., Fourage, L., Ravot, G., Jermutus, L., and Minter, R.
In vitro DNA recombination by L-Shuffling during ribosome display affinity maturation of an anti-Fas antibody increases the population of improved variants
Protein Engineering Design and Selection, vol. 21 no. 5 pp. 343–351, 2008

Download the pdf from PEDS website